显微CT(Micro-CT)可以检测哪些样本？

<div class="dpu8C _2kCxD " style="max-width: 100%; overflow-x: visible; font-size: 18px; line-height: 30px; color: #222222; margin-top: 28px; font-family: arial; background-color: #ffffff;"> <p style="overflow-y: auto; max-width: 100%; line-height: 30px; color: #000000; box-sizing: border-box; margin: 0px !important; padding: 0px !important;"><span style="max-width: 100%; margin: 0px; padding: 0px; box-sizing: border-box; outline: 0px; color: #4687dd; font-size: 12pt;"><strong style="max-width: 100%; margin: 0px; padding: 0px; box-sizing: border-box;">1、Micro-CT成像原理</strong></span></p> </div> <div class="dpu8C _2kCxD " style="max-width: 100%; overflow-x: visible; font-size: 18px; line-height: 30px; color: #222222; margin-top: 24px; font-family: arial; background-color: #ffffff;"> <p style="overflow-y: auto; max-width: 100%; line-height: 30px; color: #000000; box-sizing: border-box; margin: 0px !important; padding: 0px !important;"><span style="font-size: 12pt;"><span style="max-width: 100%;"><span style="color: #236fa1;"><a style="color: #236fa1;" title="显微CT(Micro-CT)" href="https://www.kexingtest.com/instrument/detail?id=147" target="_blank" rel="noopener">Micro-CT</a></span>成像原理是采用微焦点X线球管对小动物各个部位的层面进行扫描投射，由探测器接受透过该层面的</span><span style="max-width: 100%;">X射线</span><span style="max-width: 100%;">，转变为可见光后，由光电转换器转变为电信号，再经模拟/数字转换器转为数字信号，输入计算机进行成像。成像的整体思路如下：</span></span></p> <p style="overflow-y: auto; max-width: 100%; line-height: 30px; color: #000000; box-sizing: border-box; margin: 0px !important; padding: 0px !important;"> </p> <p style="overflow-y: auto; max-width: 100%; line-height: 30px; color: #000000; box-sizing: border-box; margin: 0px !important; padding: 0px !important;"><span style="font-size: 12pt;">当X-射线透过样本时，样本的各个部位对X-射线的吸收率不同。X-射线源发射X-射线，穿透样本，最终在X-射线检测器上成像。对样本进行180 °以上的不同角度成像，由舜百生物所使用的Micro-CT机器可以对样本进行360 °以上的不同角度成像。采用锥形束不仅能够获得真正各向同性的容积图像，提高空间分辨率，提高射线利用率，而且在采集相同3D图像时速度远远快于扇形束。通过计算机软件，将每个角度的图像进行重构，还原成在电脑中可分析的3D图像。通过软件：观察样本内部的各个截面的信息；对样本感兴趣部分进行2D和3D分析；还可以制作直观的3D动画等。</span></p> <p style="overflow-y: auto; max-width: 100%; line-height: 30px; color: #000000; box-sizing: border-box; margin: 0px !important; padding: 0px !important;"> </p> <p style="overflow-y: auto; max-width: 100%; line-height: 30px; color: #000000; box-sizing: border-box; margin: 0px !important; padding: 0px !important;"><span style="font-size: 12pt;">该技术是一种非破坏性的3D成像技术，可以在不破坏样本的情况下清楚了解样本的内部显微结构。它与普通临床的CT最大的差别在于分辨率极高，可以达到微米（μm）级别，目前国内一家自主研发Micro-CT的公司已经将分辨率提高到0.5 μm，具有良好的“显微”作用。Micro-CT可用于医学、药学、生物、考古、材料、电子、地质学等领域的研究。</span></p> <div class="dpu8C _2kCxD " style="max-width: 100%; overflow-x: visible; line-height: 30px; margin-top: 28px;"> <p style="overflow-y: auto; max-width: 100%; line-height: 30px; color: #000000; box-sizing: border-box; margin: 0px !important; padding: 0px !important;"><span style="max-width: 100%; margin: 0px; padding: 0px; box-sizing: border-box; outline: 0px; color: #4687dd; font-size: 12pt;"><strong style="max-width: 100%; margin: 0px; padding: 0px; box-sizing: border-box;">2、Micro-CT检测及应用领域</strong></span></p> <p style="overflow-y: auto; max-width: 100%; line-height: 30px; color: #000000; box-sizing: border-box; margin: 0px !important; padding: 0px !important;"> </p> <p style="overflow-y: auto; max-width: 100%; line-height: 30px; color: #000000; box-sizing: border-box; margin: 0px !important; padding: 0px !important;"><span style="font-size: 12pt;">（1）骨骼</span></p> </div> <div class="dpu8C _2kCxD " style="max-width: 100%; overflow-x: visible; line-height: 30px; margin-top: 24px;"> <p style="overflow-y: auto; max-width: 100%; line-height: 30px; color: #000000; box-sizing: border-box; margin: 0px !important; padding: 0px !important;"><span style="font-size: 12pt;">骨骼是 Micro-CT 最主要应用领域之一，其中骨小梁是主要研究对象。骨松质和骨皮质的变化与骨质疏松、骨折、骨关节炎、局部缺血和遗传疾病等病症有关。目前，Micro-CT 技术在很大程度上取代了破坏性的组织形态计量学方法。</span></p> </div> <div class="dpu8C _2kCxD " style="max-width: 100%; overflow-x: visible; line-height: 30px; margin-top: 24px;"> <p style="overflow-y: auto; max-width: 100%; line-height: 30px; color: #000000; box-sizing: border-box; margin: 0px !important; padding: 0px !important;"><span style="font-size: 12pt;">（2）牙齿及牙周组织</span></p> </div> <div class="dpu8C _2kCxD " style="max-width: 100%; overflow-x: visible; line-height: 30px; margin-top: 24px;"> <p style="overflow-y: auto; max-width: 100%; line-height: 30px; color: #000000; box-sizing: border-box; margin: 0px !important; padding: 0px !important;"><span style="font-size: 12pt;">能够从 3D 整体结构出发，对根管形态改变、龋齿破坏、牙组织密度变化、牙槽骨结构和力学特性的变化等情况进行研究。</span></p> </div> <div class="dpu8C _2kCxD " style="max-width: 100%; overflow-x: visible; line-height: 30px; margin-top: 24px;"> <p style="overflow-y: auto; max-width: 100%; line-height: 30px; color: #000000; box-sizing: border-box; margin: 0px !important; padding: 0px !important;"><span style="font-size: 12pt;">（3）生物材料</span></p> </div> <div class="dpu8C _2kCxD " style="max-width: 100%; overflow-x: visible; line-height: 30px; margin-top: 24px;"> <p style="overflow-y: auto; max-width: 100%; line-height: 30px; color: #000000; box-sizing: border-box; margin: 0px !important; padding: 0px !important;"><span style="font-size: 12pt;"><span style="max-width: 100%;">例如， 分析体外制备仿生材料</span><span style="max-width: 100%;">支架</span><span style="max-width: 100%;">的孔隙率、强度等参数，优化支架设计；扫描需要置换的组织样品，获取三维图像后输出为 STL 文件进行快速成形（CAD/CAM），等等。</span></span></p> </div> <div class="dpu8C _2kCxD " style="max-width: 100%; overflow-x: visible; line-height: 30px; margin-top: 24px;"> <p style="overflow-y: auto; max-width: 100%; line-height: 30px; color: #000000; box-sizing: border-box; margin: 0px !important; padding: 0px !important;"><span style="font-size: 12pt;">（4）疾病机制研究</span></p> </div> <div class="dpu8C _2kCxD " style="max-width: 100%; overflow-x: visible; line-height: 30px; margin-top: 24px;"> <p style="overflow-y: auto; max-width: 100%; line-height: 30px; color: #000000; box-sizing: border-box; margin: 0px !important; padding: 0px !important;"><span style="font-size: 12pt;"><span style="max-width: 100%;">例如，研究不同</span><span style="max-width: 100%;">基因</span><span style="max-width: 100%;">或信号通路对骨骼的数量或质量的影响，疾病状态对骨骼发育/修复的影响，评价高脂血症对心脏瓣膜钙化的影响，</span><span style="max-width: 100%;">细胞因子</span><span style="max-width: 100%;">对骨折后组织修复时血管生长的影响，等等。</span></span></p> </div> <div class="dpu8C _2kCxD " style="max-width: 100%; overflow-x: visible; line-height: 30px; margin-top: 24px;"> <p style="overflow-y: auto; max-width: 100%; line-height: 30px; color: #000000; box-sizing: border-box; margin: 0px !important; padding: 0px !important;"><span style="font-size: 12pt;">（5）新药开发</span></p> </div> <div class="dpu8C _2kCxD " style="max-width: 100%; overflow-x: visible; line-height: 30px; margin-top: 24px;"> <p style="overflow-y: auto; max-width: 100%; line-height: 30px; color: #000000; box-sizing: border-box; margin: 0px !important; padding: 0px !important;"><span style="font-size: 12pt;">例如，研究新的骨质疏松药物及疗效评价，Micro-CT 已经成为一种重要的临床前检测技术。</span></p> </div> <div class="dpu8C _2kCxD " style="max-width: 100%; overflow-x: visible; line-height: 30px; margin-top: 24px;"> <p style="overflow-y: auto; max-width: 100%; line-height: 30px; color: #000000; box-sizing: border-box; margin: 0px !important; padding: 0px !important;"><span style="font-size: 12pt;">（6）电子材料</span></p> </div> <div class="dpu8C _2kCxD " style="max-width: 100%; overflow-x: visible; line-height: 30px; margin-top: 24px;"> <p style="overflow-y: auto; max-width: 100%; line-height: 30px; color: #000000; box-sizing: border-box; margin: 0px !important; padding: 0px !important;"><span style="font-size: 12pt;">半导体材料和结构等。</span></p> </div> <div class="dpu8C _2kCxD " style="max-width: 100%; overflow-x: visible; line-height: 30px; margin-top: 24px;"> <p style="overflow-y: auto; max-width: 100%; line-height: 30px; color: #000000; box-sizing: border-box; margin: 0px !important; padding: 0px !important;"><span style="font-size: 12pt;">（7）地质学研究</span></p> </div> <div class="dpu8C _2kCxD " style="max-width: 100%; overflow-x: visible; line-height: 30px; margin-top: 24px;"> <p style="overflow-y: auto; max-width: 100%; line-height: 30px; color: #000000; box-sizing: border-box; margin: 0px !important; padding: 0px !important;"><span style="font-size: 12pt;">地质分布、砖石等。</span></p> </div> <div class="dpu8C _2kCxD " style="max-width: 100%; overflow-x: visible; line-height: 30px; margin-top: 24px;"> <p style="overflow-y: auto; max-width: 100%; line-height: 30px; color: #000000; box-sizing: border-box; margin: 0px !important; padding: 0px !important;"><span style="font-size: 12pt;">（8）木材、纸、植物种子等研究</span></p> </div> <div class="dpu8C _2kCxD " style="max-width: 100%; overflow-x: visible; line-height: 30px; margin-top: 24px;"> <p style="overflow-y: auto; max-width: 100%; line-height: 30px; color: #000000; box-sizing: border-box; margin: 0px !important; padding: 0px !important;"><span style="font-size: 12pt;">（9）其它</span></p> </div> <div class="dpu8C _2kCxD " style="max-width: 100%; overflow-x: visible; line-height: 30px; margin-top: 24px;"> <p style="overflow-y: auto; max-width: 100%; line-height: 30px; color: #000000; box-sizing: border-box; margin: 0px !important; padding: 0px !important;"><span style="font-size: 12pt;"><span style="max-width: 100%;">微型器件的质检和探伤，建筑材料内部孔隙度、连通度和渗透性分析，珠宝的真伪识别和最佳切割方案设计，以及化石结构分析等。</span><span style="max-width: 100%;">医疗器械</span><span style="max-width: 100%;">材料（如心脏支架、脑血管支架等）；其他材料（如水泥材料、纤维材料等）。</span></span></p> </div> </div>